Disease: Enlarged spleen (splenomegaly)


    Your spleen is an organ located just below your left rib cage. Many conditions — including infections, liver disease and some cancers — can cause an enlarged spleen, also known as splenomegaly (spleh-no-MEG-uh-lee).

    An enlarged spleen usually doesn't cause symptoms. It's often discovered during a routine physical exam. Your doctor generally can't feel a normal-sized spleen in adults but can feel an enlarged spleen. Your doctor will likely request imaging and blood tests to help identify the cause.

    Treatment for an enlarged spleen focuses on the underlying condition that's causing it. Surgically removing an enlarged spleen isn't usually the first treatment, but is sometimes recommended.

    Source: http://www.mayoclinic.com


    An enlarged spleen may cause:

    • No symptoms in some cases
    • Pain or fullness in the left upper abdomen that may spread to the left shoulder
    • Feeling full without eating or after eating only a small amount from the enlarged spleen pressing on your stomach
    • Anemia
    • Fatigue
    • Frequent infections
    • Easy bleeding

    When to see a doctor

    See your doctor promptly if you have pain in your left upper abdomen, especially if it's severe or the pain gets worse when you take a deep breath.

    Source: http://www.mayoclinic.com


    A number of infections and diseases may cause an enlarged spleen. The enlargement of the spleen may be temporary, depending on treatment. Contributing factors include:

    • Viral infections, such as mononucleosis
    • Bacterial infections, such as syphilis or an infection of your heart's inner lining (endocarditis)
    • Parasitic infections, such as malaria
    • Cirrhosis and other diseases affecting the liver
    • Various types of hemolytic anemia — a condition characterized by early destruction of red blood cells
    • Blood cancers, such as leukemia and myeloproliferative neoplasms, and lymphomas, such as Hodgkin's disease
    • Metabolic disorders, such as Gaucher's disease and Niemann-Pick disease
    • Pressure on the veins in the spleen or liver or a blood clot in these veins

    How the spleen works

    Your spleen is tucked under your rib cage next to your stomach on the left side of your abdomen. It's a soft, spongy organ that performs several critical jobs. Your spleen:

    • Filters out and destroys old, damaged blood cells
    • Prevents infection by producing white blood cells (lymphocytes) and acting as a first line of defense against disease-causing organisms
    • Stores red blood cells and platelets, which help your blood clot

    An enlarged spleen affects each of these vital functions. As your spleen grows larger, it filters normal red blood cells as well as abnormal ones, reducing the number of healthy cells in your bloodstream. It also traps too many platelets.

    Excess red blood cells and platelets eventually can clog your spleen and affect normal functioning. An enlarged spleen may even outgrow its own blood supply, which can damage or destroy sections of the organ.

    Source: http://www.mayoclinic.com


    An enlarged spleen is usually detected during a physical exam. Your doctor can often feel it by gently examining your left upper abdomen. However, in some people — especially those who are slender — a healthy, normal-sized spleen can sometimes be felt during an exam.

    Your doctor may confirm the diagnosis of an enlarged spleen with one or more of these tests:

    • Blood tests, such as a complete blood count to check the number of red blood cells, white blood cells and platelets in your system
    • Ultrasound or computerized tomography (CT) scan to help determine the size of your spleen and whether it's crowding other organs
    • Magnetic resonance imagining (MRI) to trace blood flow through the spleen

    Imaging tests aren't always needed to diagnose an enlarged spleen. But if your doctor recommends imaging, you generally don't need any special preparation for an ultrasound or MRI.

    If you're having a CT scan, however, you may need to refrain from eating before the test. If you need to prepare, your doctor will let you know well in advance.

    Finding the cause

    Sometimes you may need more testing to find the cause of an enlarged spleen, including liver function tests and a bone marrow exam. These tests can provide more-detailed information about your blood cells than can blood drawn from a vein.

    A sample of solid bone marrow is sometimes removed in a procedure called a bone marrow biopsy. Or you may have a bone marrow aspiration, which removes the liquid portion of your marrow. In many cases, both procedures are performed at the same time (bone marrow exam).

    Both the liquid and solid bone marrow samples are usually taken from the pelvis. A needle is inserted into the bone through an incision. You'll receive either general or local anesthesia before the test to ease discomfort.

    A needle biopsy of the spleen is very rare because of the risk of bleeding.

    Occasionally, your doctor may recommend surgery to remove your spleen when there's no identifiable cause for the enlargement. After surgical removal, the spleen is examined under a microscope to check for possible lymphoma of the spleen.

    Source: http://www.mayoclinic.com


    Potential complications of an enlarged spleen are:

    • Infection. An enlarged spleen can reduce the number of healthy red blood cells, platelets and white cells in your bloodstream, leading to more frequent infections. Anemia and increased bleeding also are possible.
    • Ruptured spleen. Even healthy spleens are soft and easily damaged, especially in car crashes. The possibility of rupture is much greater when your spleen is enlarged. A ruptured spleen can cause life-threatening bleeding into your abdominal cavity.

    Source: http://www.mayoclinic.com

    Lifestyle and home remedies

    Avoid contact sports — such as soccer, football and hockey — and limit other activities as recommended by your doctor. Modifying your activities can reduce the risk of a ruptured spleen.

    It's also important to wear a seat belt. If you're in a car accident, a seat belt can help prevent injury to your spleen.

    Finally, be sure to keep your vaccinations up to date because your risk of infection is increased. That means at least an annual flu shot, and a tetanus, diphtheria and pertussis booster every 10 years. Ask your doctor if you need any additional vaccines.

    Source: http://www.mayoclinic.com

    Risk factors

    Anyone can develop an enlarged spleen at any age, but certain groups are at higher risk, including:

    • Children and young adults with infections, such as mononucleosis
    • People who have Gaucher's disease, Niemann-Pick disease, and several other inherited metabolic disorders affecting the liver and spleen
    • People who live in or travel to areas where malaria is common

    Source: http://www.mayoclinic.com

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