Churg-Strauss syndrome is a highly variable illness. Some people have only mild symptoms. Others experience severe or life-threatening complications.
Churg-Strauss syndrome has three stages, or phases, each with its own signs and symptoms. Not everyone develops all three phases. Nor do the phases always arise in the same order. This is especially true when the disease is caught and treated before the most serious damage occurs.
This is usually the first stage of Churg-Strauss syndrome. It's marked by a number of allergic reactions, including:
Asthma. The primary sign of Churg-Strauss syndrome, asthma develops on average three to nine years before other signs and symptoms appear. In people with Churg-Strauss syndrome who already have asthma, symptoms usually become worse and may require steroids for control.
Other people develop what is known as late-onset asthma. Developing asthma, even later in life, doesn't necessarily mean that you have Churg-Strauss syndrome.
- Hay fever (allergic rhinitis). This affects the mucous membranes of your nose, causing a runny nose, sneezing and itching.
- Sinus pain and inflammation (sinusitis). You may experience facial pain and develop nasal polyps, which are soft, noncancerous (benign) growths that develop as a result of chronic inflammation.
An eosinophil is a type of white blood cell that helps your immune system fight certain infections. Normally, eosinophils make up only a small percentage of white blood cells. In people with Churg-Strauss syndrome, abnormally high numbers of these cells (hypereosinophilia) are found in the blood or tissues, where they can cause serious damage.
Signs and symptoms of hypereosinophilia depend on which part of your body is affected. Your lungs and digestive tract â including your stomach and esophagus â are involved most often.
Signs and symptoms of the hypereosinophilia phase may include:
- Loss of appetite and weight loss
- Night sweats
- Joint pain
- Abdominal pain and gastrointestinal bleeding
The hallmark of this stage of Churg-Strauss syndrome is severe blood vessel inflammation (vasculitis). By narrowing blood vessels, inflammation reduces blood flow to vital organs and tissues throughout your body, including your skin, heart, peripheral nervous system, muscles, bones and digestive tract. Occasionally, your kidneys also may be affected.
Depending on which organs are affected, you may experience:
- Weakness, fatigue or a general feeling of being unwell
- Unintended weight loss
- Swollen lymph nodes
- Rash or skin sores
- Joint aches and swelling
- Severe pain, numbness and tingling in your hands and feet (peripheral neuropathy)
- Severe abdominal pain
- Diarrhea, nausea and vomiting
- Shortness of breath (dyspnea) from asthma or congestive heart failure
- Chest pain
- Irregular heartbeat
- Blood in your urine (hematuria)
When to see a doctor
See your doctor anytime you develop signs and symptoms such as breathing difficulties or a runny nose that doesn't go away, especially if it's accompanied by persistent facial pain. Also see your doctor if you have asthma or hay fever that suddenly worsens.
Churg-Strauss syndrome is rare, and it's more likely that these symptoms have some other cause. But it's important that your doctor evaluate them. When the condition is diagnosed and treated early, it's more like that you'll have a good outcome and a reduced risk of complications from the disease and its treatment.