Disease: Churg-Strauss Syndrome

    Churg-Strauss syndrome facts

    • Churg-Strauss syndrome is a disease characterized by inflammation of the blood vessels.
    • Churg-Strauss syndrome occurs in patients with a history of asthma or allergy.
    • Symptoms of Churg-Strauss syndrome include fatigue, weight loss, nasal passage inflammation, numbness, and weakness.
    • The ultimate test for the diagnosis is a biopsy of involved tissue.
    • Treatment of Churg-Strauss syndrome involves stopping inflammation and suppressing the immune system.

    What is Churg-Strauss syndrome?

    Churg-Strauss syndrome is one of many forms of vasculitis. Vasculitis diseases are characterized by inflammation of blood vessels. Churg-Strauss syndrome, in particular, occurs in patients with a history of asthma or allergy and features inflammation of blood vessels (also referred to as angiitis) in the lungs, skin, nerves, and abdomen. The blood vessels involved in Churg-Strauss syndrome are small arteries and veins.

    What causes Churg-Strauss syndrome?

    Churg-Strauss syndrome is rare. The cause of the syndrome is not known, but it involves an abnormal over-activation of the immune system in a person with underlying bronchospastic lung disease (asthma). While Churg-Strauss syndrome has been reported to be associated with certain asthma medications, called leukotriene modifiers, whether they actually cause the disease or whether the patients that take them have more severe asthma that lends a tendency toward the development of Churg-Strauss is not yet clear.

    What are symptoms of Churg-Strauss syndrome?

    Churg-Strauss syndrome causes fever, weight loss, and sinus or nasal passage inflammation in the patient with asthma. Fatigue is common. Sometimes the asthma actually improves somewhat as the disease intensifies elsewhere. Cough, shortness of breath, and chest pain can occur as the lungs are affected by vasculitis.

    Skin lumps, called nodules, can appear on the extremities. Diarrhea and pain in the belly occur due to blood vessel inflammation within the abdomen. The bladder and prostate gland can become inflamed.

    Numbness or weakness of the extremities is the result of nerve injury from the vasculitis. If the brain is affected, seizures or confusion can occur.

    How is Churg-Strauss syndrome diagnosed?

    Churg-Strauss syndrome is suggested when the symptoms described above occur in a patient with a history of asthma.

    Abnormalities of the lungs, skin, and nerves might be noted by the doctor during the examination. Blood pressure can be elevated.

    Blood examination generally shows elevated levels of an uncommon white blood cell, called an eosinophil, and other white blood cells are also elevated in number. Kidney function blood tests and urinalysis can be abnormal when the kidneys are affected (which is not common).

    If the lungs are inflamed, the chest x-ray image or CT scan of the chest can demonstrate areas of inflammation.

    The ultimate test for the diagnosis is a biopsy of involved tissue, which demonstrates a characteristic pattern of inflammation visible under a microscope. Eosinophil are also seen accumulated in the abnormal tissue.

    What are symptoms of Churg-Strauss syndrome?

    Churg-Strauss syndrome causes fever, weight loss, and sinus or nasal passage inflammation in the patient with asthma. Fatigue is common. Sometimes the asthma actually improves somewhat as the disease intensifies elsewhere. Cough, shortness of breath, and chest pain can occur as the lungs are affected by vasculitis.

    Skin lumps, called nodules, can appear on the extremities. Diarrhea and pain in the belly occur due to blood vessel inflammation within the abdomen. The bladder and prostate gland can become inflamed.

    Numbness or weakness of the extremities is the result of nerve injury from the vasculitis. If the brain is affected, seizures or confusion can occur.

    How is Churg-Strauss syndrome diagnosed?

    Churg-Strauss syndrome is suggested when the symptoms described above occur in a patient with a history of asthma.

    Abnormalities of the lungs, skin, and nerves might be noted by the doctor during the examination. Blood pressure can be elevated.

    Blood examination generally shows elevated levels of an uncommon white blood cell, called an eosinophil, and other white blood cells are also elevated in number. Kidney function blood tests and urinalysis can be abnormal when the kidneys are affected (which is not common).

    If the lungs are inflamed, the chest x-ray image or CT scan of the chest can demonstrate areas of inflammation.

    The ultimate test for the diagnosis is a biopsy of involved tissue, which demonstrates a characteristic pattern of inflammation visible under a microscope. Eosinophil are also seen accumulated in the abnormal tissue.

    Source: http://www.rxlist.com

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